All-American, SEC Pitcher of the Year, First-team All-SEC, Second-team All-SEC
| Season | Pos | App | W | L | ERA | IP | K | SV |
|---|---|---|---|---|---|---|---|---|
| 2023 | P | 28 | 9 | 7 | 3.05 | 87.1 | 99 | 2 |
| 2024 | P | 38 | 22 | 7 | 1.12 | 188.1 | 225 | 1 |
| 2025 | P | 44 | 25 | 11 | 1.17 | 226.2 | 306 | 3 |
| 2026 | P | 34 | 15 | 8 | 1.7 | 148 | 194 | 7 |
Best season: 2025 (25-11 · 1.17 ERA · 306 K · 226.2 IP).
Compare Karlyn Pickens with another Vol · All Tennessee softball players